Contrast enhanced renal MR angiography at 7 Tesla: How much gadolinium do we need?

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• 作者：Karsten Beiderwellen^a ; ^b ; ^{karsten.beiderwellen@uni-due.de} ; Oliver Kraff^b ; ^{Oliver.kraff@uni-due.de} ; Anja Laader^a ; ^b ; ^{anja.laader@uk-essen.de} ; Stefan Maderwald^b ; ^{Stefan.maderwald@uni-due.de} ; Stephan Orzada^b ; ^{Stephan.orzada@uni-due.de} ; Mark E. Ladd^c ; ^{mark.ladd@dkfz-heidelberg.de} ; Michael Forsting^a ; ^b ; ^{Michael.forsting@uk-essen.de} ; Thomas C. Lauenstein^a ; ^{Thomas.Lauenstein@uni-due.de} ; Lale Umutlu^a ; ^b ; ^{Lale.umutlu@uk-essen.de}
• 关键词：BW ; body weight ; CR ; contrast ratio ; CTA ; computed tomography angiography ; DSA ; digital subtraction angiography ; FLASH ; fast low angle shot ; FOV ; field of view ; Gd ; gadolinium ; MR ; magnetic resonance ; MRA ; magnetic resonance angiography ; NSF ; nephrogenic systemic fibrosis ; T ; Tesla
• 刊名：European Journal of Radiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：86
• 期：Complete
• 页码：76-82
• 全文大小：1057 K
• 卷排序：86

文摘

To investigate whether a dose reduction of Gadobutrol for renal magnetic resonance angiography (MRA) at 7 Tesla (T) is feasible while preserving diagnostic image quality.MethodsTen healthy volunteers were enrolled for a renal MRA on a 7 T scanner. Fast low angle shot (FLASH) MRA data sets were obtained utilizing three different doses of Gadobutrol (0.1, 0.05 and 0.025 mmol/kg body weight [BW]). Contrast ratios (CR) were measured in the aorta as well as in the intra- and extraparenchymal arteries compared to the psoas muscle. Qualitative analysis regarding the delineation of vessel structures was performed using a four-point-scale.ResultsAll doses of Gadobutrol allowed for a good delineation of the aorta and renal arteries. For the extra- and intraparenchymal segmental arteries higher values were observed for full and half dose in comparison to quarter dose. No significant difference was observed for full and half dose. A lower CR was observed for quarter compared to half dose (p < 0.05) for the renal arteries.ConclusionsWhile best results were observed for half and full dose, a dose reduction to 0.025 mmol/kg BW is justifiable, maintaining a diagnostic image quality. This may be of high interest considering patients with renal impairment.