A prospective study on the impact of heart rate control achieved with metoprolol on cardiac performance, motor function and quality of life in Chinese chronic heart failure patients

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• 作者：Yong Meng ; ^{mengyong76@gmail.com} ; Xuelu Liu ; Juan Liu ; Xianliang Cheng
• 关键词：ACEIs ; Angiotensin Converting Enzyme Inhibitors ; ARBs ; Angiotensin Receptor Blockers ; CHF ; Chronic Heart Failure ; CI ; Cardiac Index ; CO ; Cardiac Output ; GFR ; Glomerular Filtration Rate ; HR ; Heart Rate ; LVEF ; Left Ventricular Ejection Fraction ; METs ; Metabolic Equivalents ; MLHFQ ; Minnesota Living With Heart Failure Questionnaire ; 6MWT ; 6-Minute Walk Test ; NYHA ; New York Heart Association ; QoL ; Quality of Life ; SBP ; Systolic Blood Pressure ; SF-8 ; Short Form-8 Questionnaire ; VSAQ ; Veterans Specific
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：267-271
• 全文大小：239 K
• 卷排序：227

文摘

To prospectively evaluate the impact of metoprolol achieved heart rate (HR) on cardiac-motor function and quality of life (QoL) in chronic heart failure (CHF) patients.Methods and resultsBetween February 2013 to April 2016, association of HR reduction with haemodynamic indices, motor function and QoL in CHF patients with HR > 80 bpm receiving metoprolol 23.75 mg or 47.5 mg q.d was studied. Overall, 154 patients (median age, 66.39 years; males, n = 101; females, n = 53) were enrolled, whose average resting HR decreased significantly from baseline value of 82.72 ± 6.73 to 69.38 ± 3.57, 67.72 ± 2.61, 66.50 ± 3.14 and 64.86 ± 3.21 bpm in the 1st, 3rd, 6th and 12th months post metoprolol intervention, respectively (P < 0.0001). Similarly, the ejection fraction (r = − 0.6461, P < 0.0001), cardiac output (r = − 0.5238, P < 0.0001), cardiac index (r = − 0.5378, P < 0.0001) and veterans specific activity questionnaire scores (r = − 0.4088, P < 0.0001) were significantly associated with the reduction in HR after 12 months. The improvement in 6-min walk test was independent of HR reduction (P = 0.005). Similarly, QoL as measured by short form-8 questionnaire (SF-8) but not Minnesota Living with Heart Failure was significantly improved at the 12th–month. However, this was not associated with the reductions in HR.ConclusionMetoprolol achieved HR control was associated with improvement in cardiac performance and motor function but not QoL in patients with CHF.