Angiotensin II AT₁ receptors mediate neuronal sensitization and sustained blood pressure response induced by a single injection of amphetamine

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• 作者：N.A. Marchese^a ; ¹ ; M.C. Paz^a ; ¹ ; X. Caeiro^b ; F.M. Dadam^b ; G. Baiardi^c ; M.F. Perez^a ; C. Bregonzio^a ; ^{bregonzio@fcq.unc.edu.ar}
• 关键词：A1 ; caudal ventrolateral medulla ; Amph ; Amphetamine ; AT1-R ; AT1 receptors ; CeAmy ; central amygdala ; LC ; locus coeruleus ; NA ; noradrenaline ; NTS ; nucleus of the solitary tract ; RAS ; renin&ndash ; angiotensin systems ; TH ; tyrosine hydroxylase
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：521-529
• 全文大小：758 K
• 卷排序：340

文摘

Amphetamine-induced c-Fos sensitization is observed in TH + neurons within LC and NTS. Amphetamine exposure induces a sensitized blood pressure response. Orally administered AT1 receptor blocker decreases LC spontaneous activity. AT1 receptor blocker prevents amphetamine-induced c-Fos sensitization in TH + neurons within LC and NTS. AT1 receptor blocker prevents amphetamine-induced sensitized blood pressure response.