Animal models of colorectal cancer with liver metastasis

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• 作者：Bo Young Oh^a ; Hye Kyung Hong^b ; Woo Yong Lee^a ; ^c ; Yong Beom Cho^a ; ^c ; ^d ; ^{gscyb@skku.edu}
• 关键词：Colorectal cancer ; Liver metastasis ; Mouse model ; Orthotopic model ; Genetically engineered mouse model ; Xenografts
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：387
• 期：Complete
• 页码：114-120
• 全文大小：934 K
• 卷排序：387

文摘

No animal model is fully representative of metastasis in human cancer. Spontaneous liver metastasis models represent all steps of metastasis. Experimental liver metastasis models are highly reproducible and consistent. PDX models are useful for predicting patient-specific drug response. GEMMs represent the natural course of cancer, but liver metastases seldom develop.