Structural features of heparanase-inhibiting non-anticoagulant heparin derivative Roneparstat
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- 作者：Anna Alekseevaa ; anna.v.alekseeva@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Giulia Mazzinib ; giulia.mazzini@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Giuseppe Gianninic ; Giuseppe.Giannini@sigma-tau.it" class="auth_mail" title="E-mail the corresponding author ; Annamaria Naggia ; b
- 关键词：gs ; glycol-split ; LMWH ; low-molecular weight heparin ; U ; uronic acid ; I ; l-iduronic acid ; G ; d-glucuronic acid ; I2S ; l-iduronic acid 2-O-sulfate ; ANS6S ; d-glucosamine-N ; 6-O-disulfate ; ANAc ; N-acetylated d-glucosamine ; ANS3S6S ; d-glucosamine N ; 3-O ; 6-O-trisulfate ; ΔU2S ; 4 ; 5-unsaturated uronic acid 2-O-sulfate ; R ; remnant of the gs-uronic acid ; Gal ; d-galactose ; Xyl ; d-xylose ; Ser ; l-serine ; ATBR ; antithrombin-binding region ; RE ; reducing end ; NRE ; non-reducing end ; LR ; linkage region
- 刊名：Carbohydrate Polymers
- 出版年：2017
- 出版时间：20 January 2017
- 年：2017
- 卷：156
- 期：Complete
- 页码：470-480
- 全文大小：1473 K
文摘
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Structural features of Roneparstat (SST0001) have been determined at the first time.
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Its structural features relevant for binding with proteins have been summarized.
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Internal sequences as well as end groups of SST0001 have been characterized.
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Combination of SEC-TDA, NMR and LC/MS, are required for SST0001 detailed analysis.
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The obtained results provide criteria for structural characterization of SST0001.