Reconstruction and analysis of a genome-scale metabolic network of Corynebacterium glutamicum S9114
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- 作者：Jie Meia ; b ; c ; Nan Xua ; b ; c ; Chao Yea ; b ; c ; Liming Liua ; b ; c ; mingll@jiangnan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jianrong Wub
- 关键词：GSMM ; genome-scale metabolic model ; BLAST ; Basic Local Alignment Search Tool ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; KAAS ; KEGG Automatic Annotation Server ; NCBI ; National Center for Biotechnology Information ; RAST ; the rapid annotation using subsystem technology server ; COBRA ; Constraint-based Reconstruction and Analysis ; GLPK ; GNU Linear Programming Kit ; ELLO ; Subcellular Localization Predictor ; TCDB ; the transporter classification database ; FBA ; flux balance analysis ; PPP ; pentose pho
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：615-622
- 全文大小：1032 K
文摘
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We reconstructed the genome-scale metabolic model for C. glutamicum S9114.
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The model was validated by cell growth on 25 carbon sources and 14 nitrogen sources.
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Four key metabolic nodes were identified to be essential for glutamate production.
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Targets for improving γ-aminobutyrate and l-isoleucine production were predicted.