Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells
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- 作者：Belinda Halling Sø ; rensena ; Celina Stø ; ving Dama ; b ; Stefan Stü ; rupb ; Ian Henry Lamberta ;
- 关键词：A2780WT ; drug-sensitive human ovarian cancer cells ; A2780CisR ; cisplatin resistant A2780 cells ; ABC ; ATP-binding cassette ; Ano6 ; Anoctamin 6 ; Apaf-1 ; apoptotic protease activating factor 1 ; Atox1 ; Antioxidant 1 copper chaperone ; AP ; alkaline phosphatase ; ATP7A/ATP7B ; copper-transporting P-type ATPases ; AVD ; apoptotic volume decrease ; BCIP ; 5-bromo-4-chloro-3-indolyl-phosphate ; CTR ; copper transport receptor ; DIDS ; 4 ; 4&prime ; -Diisothiocyanatostilbene-2 ; 2&prime ; -disulfonic acid disodium salt hydra
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：287-295
- 全文大小：1043 K
文摘
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Cisplatin (Pt) accumulation is increased by cell swelling and membrane depolarization.
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10">Pt uptake correlates with Leucine-Rich-Repeat-Containing protein 8A (LRRC8A) expression.
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LRRC8A is essential for volume sensitive osmolyte transport.
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Cisplatin resistance correlates with reduced LRRC8A expression and Pt accumulation.