The importance of the hypothalamo-pituitary-adrenal axis as a therapeutic target in anorexia nervosa

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• 作者：Rami Bou Khalil^a ; ^{ramiboukhalil@hotmail.com} ; Lama Souaiby^b ; Nassim Farè ; s^c
• 关键词：Anorexia nervosa ; Hypothalamo-pituitary-adrenal axis ; Insula ; Mifepristone ; RU486
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：171
• 期：Complete
• 页码：13-20
• 全文大小：424 K
• 卷排序：171

文摘

A pharmacological approach to the treatment of anorexia nervosa (AN) is suggested. The hypothalamic-pituitary-adrenal (HPA) axis maintains AN pathophysiology. Insular and frontal functions generate negative emotions in patients with AN. Mifepristone (RU486) may counteract these mechanisms improving symptoms of AN.