Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes
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- 作者：Xiaoqin Luoa ; b ; Zhenyu Luoa ; Zihui Zhanga ; Haixia Yanga ; b ; Baochang Laia ; Qinyu Yaoa ; Lei Xiaoa ; Nanping Wanga ; c ; nanpingwang2003@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hyperhomocysteinemia ; Homocysteine ; Hepcidin ; BMP6/SMAD ; Hepatocytes
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：4 March 2016
- 年：2016
- 卷：471
- 期：2
- 页码：303-308
- 全文大小：957 K
文摘
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There are no studies on effects of Hcy on hepcidin expressions in hepatocytes.
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Hcy dose-dependently increased both hepcidin transcript levels and protein levels.
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Hcy activated BMP6 signaling and increased the phosphorylation of SMAD1/5/8.
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Hcy's effect on hepcidin expression was impaired by the knockdown of BMP6 and its receptors ALK2/3/6.
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