Retinoid acid receptor-related orphan receptor alpha (RORα) regulates macrophage M2 polarization via activation of AMPKα

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• 作者：Lei Xiao^a ; ¹ ; Zihui Zhang^a ; ¹ ; Xiaoqin Luo^a ; Haixia Yang^a ; Fan Li^a ; Nanping Wang^a ; ^b ; ^{nanpingwang2003@yahoo.com}
• 关键词：RORα ; retinoic acid receptor related orphan receptor α ; CH-S ; cholesterol sulfate ; LPS ; lipopolysaccharides ; AMPKα ; adenosine monophosphate (AMP)-activated protein kinase α ; ACC ; acetyl-CoA carboxylase 1 ; Comp C ; compound C ; TLR ; toll like receptor ; IFN-γ ; interferon-γ ; ROS ; reactive oxygen species ; iNOS ; inducible nitric oxide synthase ; TNF-α ; tumor necrosis factor α ; CSF ; colony-stimulating factor ; VEGF ; vascular endothelial growth factor ; TGF-β ; transforming growth factor β ; Arg1 ; arginase1
• 刊名：Molecular Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：80
• 期：Complete
• 页码：17-23
• 全文大小：1742 K
• 卷排序：80

文摘

RORα agonist CH-S promotes macrophage M2 polarization. Overexpression of RORα promotes macrophage M2 polarization. CH-S promoted M2 polarization via a RORα-dependent mechanism. RORα activation induced the activation of AMPKα. Inhibition of AMPKα abrogated RORα induced macrophage polarization.