Opioids and TRPV1 in the peripheral control of neuropathic pain - Defining a target site in the injured nerve
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- 作者：Dominika Labuz dominika.labuz@charite.de" class="auth_mail" title="E-mail the corresponding author ; Viola Spahn viola.spahn@charite.de" class="auth_mail" title="E-mail the corresponding author ; Melih Ö ; zgü ; r Celik ozgur.celik@charite.de" class="auth_mail" title="E-mail the corresponding author ; Halina Machelska ; halina.machelska@charite.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuropathy ; Opioid receptor agonist ; TRPV1 antagonist ; TRPV1 expression
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：330-340
- 全文大小：701 K
文摘
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Peripheral TRPV1 blockade alleviates neuropathic pain.
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TRPV1 antagonist is more effective after intraplantar than perineural injection.
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Opioid/TRPV1 antagonist combinations at both locations are partially effective.
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Primary action site identification in damaged nerves is crucial for efficient analgesia.