One pot three component synthesis of spiro [indolo-3,10′-indeno[1,2-b] quinolin]-2,4,11′-triones as a new class of antifungal and antimicrobial agents

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• 作者：Kalawati Meena^a ; Sudesh Kumari^a ; Jitender M. Khurana^a ; ^{jmkhurana1@yahoo.co} ; ^{injmkhurana@chemistry.du.ac.in} ; Amita Malik^b ; Chetan Sharma^c ; Harsh Panwar^c
• 关键词：Multicomponent reactions ; Isatin ; Spirooxindole ; Heterocycles ; Antimicrobial activity
• 刊名：Chinese Chemical Letters
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：136-142
• 全文大小：1284 K
• 卷排序：28

文摘

A simple and efficient three component procedure has been developed for the synthesis of highly substituted spiro[indolo-3,10′-indeno[1,2-b]quinolin]-2,4,11′-triones by one pot three component condensation of enaminones, isatin and indane-1,3-dione in ethanol:water (1:1) in presence of ceric ammonium nitrate (CAN) as catalyst. This method provides several advantages such as lesser reaction time, high yield of products and operational simplicity. The antimicrobial activity of some of the compounds has been investigated against six microbial strains, some of the tested compounds showed good antimicrobial activity.