Antifungal pharmacodynamics: Latin America's perspective

详细信息    查看全文

• 作者：Javier M. Gonzalez^a ; ^b ; Carlos A. Rodriguez^b ; Maria Agudelo^b ; ^c ; Andres F. Zuluaga^b ; Omar Vesga^b ; ^c ; ^{omar.vesga@udea.edu.co}
• 关键词：Antifungal agents ; Pharmacology ; Pharmacodynamics ; Pharmacokinetics ; Candidiasis ; Aspergillosis
• 刊名：The Brazilian Journal of Infectious Diseases
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：21
• 期：1
• 页码：79-87
• 全文大小：1184 K
• 卷排序：21

文摘

The current increment of invasive fungal infections and the availability of new broad-spectrum antifungal agents has increased the use of these agents by non-expert practitioners, without an impact on mortality. To improve efficacy while minimizing prescription errors and to reduce the high monetary cost to the health systems, the principles of pharmacokinetics (PK) and pharmacodynamics (PD) are necessary. A systematic review of the PD of antifungals agents was performed aiming at the practicing physician without expertise in this field. The initial section of this review focuses on the general concepts of antimicrobial PD. In vitro studies, fungal susceptibility and antifungal serum concentrations are related with different doses and dosing schedules, determining the PD indices and the magnitude required to obtain a specific outcome. Herein the PD of the most used antifungal drug classes in Latin America (polyenes, azoles, and echinocandins) is discussed.