Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines

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• 作者：Masayuki Hayashi^a ; ^b ; ^c ; Taiki Aoshi^a ; ^c ; ¹ ; Yasunari Haseda^a ; ^c ; ¹ ; Kouji Kobiyama^a ; ^c ; ² ; Edward Wijaya^d ; Noriyuki Nakatsu^e ; Yoshinobu Igarashi^e ; Daron M. Standley^d ; Hiroshi Yamada^e ; Yoshikazu Honda-Okubo^f ; Hiromitsu Hara^g ; ^h ; Takashi Saitoⁱ ; ^j ; Toshiyuki Takai^k ; Cevayir Coban^l ; Nikolai Petrovsky^f ; ^m ; Ken J. Ishii^a ; ^c ; ^{kenishii@biken.osaka-u.ac.jp} ; ^{kenishii@nibiohn.go.jp}
• 关键词：Vaccine ; Adjuvant ; Particle ; Inulin ; Macrophage
• 刊名：EBioMedicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：15
• 期：Complete
• 页码：127-136
• 全文大小：1523 K
• 卷排序：15

文摘

Advax potentiates built-in adjuvant property of vaccine antigens. Advax does not change the T helper immune bias induced by the vaccine antigen. Dendritic cells, phagocytic macrophages, and tumor necrosis factor-α play a role in Advax adjuvant activity.Adjuvants are indispensable agent to maximize the efficacy of vaccines. Most adjuvants consistently impart either T helper (Th)1, Th2 or Th17 bias to the vaccine response regardless of the properties of antigen. For example alum adjuvants consistently impart a Th2 bias regardless of the vaccine antigen. Here we show that a delta inulin-derived microparticle adjuvant, Advax, is an additional class of adjuvant that functions as an amplifier of in-built adjuvant activity within the antigens themselves. Advax enhances different types of adaptive immune response dependent on the antigen's own in-built adjuvant properties, confirming Advax's utility as a general purpose vaccine adjuvant.