Novel metalloantimalarials: Transmission blocking effects of water soluble Cu(I), Ag(I) and Au(I) phosphane complexes on the murine malaria parasite Plasmodium berghei

详细信息    查看全文

• 作者：Sofia Tapanelli^a ; Annette Habluetzel^a ; ^{annette.habluetzel@unicam.it} ; Maura Pellei^b ; ^{maura.pellei@unicam.it} ; Luciano Marchiò ; ^c ; Alessia Tombesi^b ; Ambra Capparè ; ^b ; Carlo Santini^b
• 关键词：Copper(I) ; Silver(I) ; Gold(I) ; Phosphane complexes ; Antimalarials ; Transmission blocking
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：1-4
• 全文大小：395 K
• 卷排序：166

文摘

Water soluble metal phosphane complexes show evidence as novel metalloantimalarials. Cu(I), Ag(I) and Au(I) complexes of tris(hydroxymethyl)phosphane(thp) were studied. [Ag(thp)4]PF6 interferes with transmissible stages of the malaria parasite in vitro. [Ag(thp)4]PF6 inhibits sporogonic development of Plasmodium at low micromolar doses. The X-ray crystal structure of [Ag(thp)4]PF6 exhibits a regular tetrahedral geometry.