Sonodynamic inactivation of Gram-positive and Gram-negative bacteria using a Rose Bengal-antimicrobial peptide conjugate

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• 作者：David Costley^a ; Heather Nesbitt^a ; Nigel Ternan^a ; James Dooley^a ; Ying-Ying Huang^b ; ^c ; Michael R. Hamblin^b ; ^c ; Anthony P. McHale^a ; John F. Callan^a ; ^{j.callan@ulster.ac.uk}
• 关键词：Sonodynamic therapy ; Antimicrobial ; Sensitiser ; Peptide
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：1
• 页码：31-36
• 全文大小：1335 K
• 卷排序：49

文摘

Potential use of antimicrobial sonodynamic therapy (ASDT) as antibiotic-free treatment for localised infection. Broad-spectrum efficacy of ASDT using a sensitiser–antimicrobial peptide hybrid. In vivo demonstration of ASDT in a murine model of localised infection. Ability of low-intensity ultrasound to enhance uptake of sensitisers in bacterial biofilms.