HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice

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• 作者：Crystal R. Leibrand^a ; ¹ ; Jason J. Paris^b ; ¹ ; M. Said Ghandour^c ; Pamela E. Knapp^b ; ^c ; ^d ; Woong-Ki Kim^e ; Kurt F. Hauser^b ; ^c ; ^d ; MaryPeace McRae^a ; ^{mpmcrae@vcu.edu}
• 关键词：ALCAM ; activated leukocyte cell adhesion molecule ; ANOVA ; analysis of variance ; BBB ; blood-brain barrier ; cART ; combination antiretroviral therapy ; CNS ; central nervous system ; HAND ; HIV associated neurocognitive disorders ; HIV-1 ; human immunodeficiency virus-1 ; HRP ; horseradish peroxidase ; Iba1 ; ionized calcium-binding adaptor molecule 1 ; ICV ; intracerebroventricular ; JAM-A ; junctional adhesion molecule-A ; Na-F ; sodium fluorescein ; SIV ; simian immunodeficiency virus ; Tat ; trans-activator of tra
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：640
• 期：Complete
• 页码：136-143
• 全文大小：2441 K
• 卷排序：640

文摘

HIV-1 Tat exposure disrupted the BBB, as evidenced by Na-F and HRP leakage into the brain. HIV-1 Tat exposure increased phagocytic macrophages/microglia within the caudate/putamen. HIV-1 Tat activated both perivascular and tissue-resident macrophages/microglia.