The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

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• 作者：Jonathan Matalonga¹ ; Estibaliz Glaria¹ ; Mariana Bresque² ; Carlos Escande² ; José ; Marí ; a Carbó ; ¹ ; Kerstin Kiefer³ ; Ruben Vicente³ ; Theresa E. Leó ; n¹ ; Susana Beceiro⁴ ; Mó ; nica Pascual-Garcí ; a¹ ; Joan Serret⁵ ; Lucí ; a Sanjurjo⁶ ; Samantha Moró ; n-Ros¹ ; Antoni Riera⁷ ; ⁸ ; Sonia Paytubi⁹ ; Antonio Juarez⁹ ; ¹⁰ ; Fernando Sotillo⁷ ; Lennart Lindbom¹¹ ; Carme Caelles¹² ; Maria-Rosa Sarrias⁶ ; Jaime Sancho¹³ ; Antonio Castrillo⁴ ; Eduardo N. Chini¹⁴ ; Annabel F. Valledor¹ ; ¹⁵ ; ^{afernandezvalledor@ub.edu}
• 关键词：macrophage ; nuclear receptor ; LXR ; bacterial infection ; NAD ; cytoskeleton ; CD38
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1241-1255
• 全文大小：5000 K
• 卷排序：18

文摘

LXR agonists reduce intracellular NAD levels through induction of CD38 Activation of LXRs impairs cytoskeletal changes associated with bacterial infection The LXR-CD38 circuit protects host macrophages from extensive bacterial infection Activation of the LXR-CD38 circuit ameliorates clinical signs of infection in vivo