The macrocyclic effect and vasodilation response based on the photoinduced nitric oxide release from trans-[RuCl(tetraazamacrocycle)NO]²⁺

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• 作者：Fabiana de Souza Oliveira ; Kleber Queiroz Ferreira ; Daniella Bonaventura ; Luziane M. Bendhack ; Antonio Claudio Tedesco ; Sergio de P. Machado ; Elia Tfouni ; Roberto Santana da Silva
• 关键词：Nitrosyl ruthenium complexes ; Nitric oxide ; Macrocycle ; Tetraazamacrocycle ; Photochemistry
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：101
• 期：2
• 页码：313-320
• 全文大小：451 K

文摘

Irradiation of trans-[RuCl(cyclam)(NO)]²⁺, cyclam is 1,4,8,11-tetraazacyclotetradecane, at pHs 1–7.4, with near UV light results in the release of NO and formation of trans-[Ru^IIICl(OH)(cyclam)]⁺ with pH dependent quantum yields (from 0.01 to 0.16 mol Einstein⁻¹) lower than that for trans-[RuCl([15]aneN₄)(NO)]²⁺, [15]aneN₄ is 1,4,8,12-tetaazacyclopentadecane, (0.61 mol Einstein⁻¹). After irradiation with 355 nm light, the trans-[RuCl([15]aneN₄)(NO)]²⁺ induces relaxation of the aortic ring, whereas the trans-[RuCl(cyclam)(NO)]²⁺ complex does not. The relaxation observed with trans-[RuCl([15]aneN₄)(NO)]²⁺ is consistent with a larger quantum yield of release of NO from this complex.