Redirection of allergen-specific T_H2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release

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• 作者：Lucia Filì ; Simona Ferri ; Francesco Guarna ; Salvatore Sampognaro ; Cinzia Manuelli ; Francesco Liotta ; Lorenzo Cosmi ; Andrea Matucci ; Aless ; ra Vultaggio ; Francesco Annunziato ; Enrico Maggi ; Antonio
• 关键词：Adjuvants ; immunotherapy ; heterocycles ; Toll-like receptors ; allergy ; T_H1/T_H2 lymphocytes ; GATA-3 ; T-box expressed in T cells ; nuclear factor κ ; B
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2006
• 出版时间：August 2006
• 年：2006
• 卷：118
• 期：2
• 页码：511-517
• 全文大小：362 K

文摘

Mycetoma is a rare and little-known pathology in Tunisia. This paper presents 13 observations gathered over 13 years (seven actinomycosic mycetoma and six fungium). All the patients presented traditional lesions: fistulated tumefactions, located on the foot in seven cases. 12 patients presented grains (white in six cases, black in four cases and yellow in two cases). The causal agent was identified seven times: Actinomadura madurae (3 times), Madurella mycetomatis (3 times) and Pseudallescheria boydii (1 time). After medical and/or surgical treatment, all the patients showed improvement in the short term.