Involvement of 3D osteoblast migration and bone apatite during in vitro early osteocytogenesis
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- 作者：Marc Robina ; Claudia Almeidaa ; Thierry Azaï ; sa ; Bernard Hayea ; Corinne Illoula ; Julie Lesieurb ; Marie-Madeleine Giraud-Guillea ; Nadine Nassifa ; nadine.nassif@upmc.fr" class="auth_mail" title="E-mail the corresponding author ; Christophe Hé ; larya ; christophe.helary@upmc.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteoblast ; Osteocyte differentiation ; Migration ; Bone apatite ; Nanotopography
- 刊名：Bone
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：146-156
- 全文大小：1501 K
文摘
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We provide evidence for a new pathway for osteocytogenesis via osteoblast migration.
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Bone apatite appears as a stimulus for osteoblast migration inside the matrix and differentiation into early osteocytes.
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We used synthetic bone-like apatite platelets in terms of structure and properties.
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Osteoblasts were cultured on osteoid-like matrices in terms of collagen density, texture and 3D features.
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Our results promise original models to study fundamental questions on biomineralization.