Apolipoprotein E genotype influences spatial distribution of cerebral microbleeds

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• 作者：Elizabeth Loehrer ; M. Arfan Ikram ; Saloua Akoudad ; Henri A. Vrooman ; Aad van der Lugt ; Wiro J. Niessen ; Albert Hofman ; Meike W. Vernooij
• 关键词：Cerebral microbleeds ; Epidemiology ; Risk factor ; APOE ; Population-based ; MRI ; Imaging marker ; Cerebrovascular disease
• 刊名：Neurobiology of Aging
• 出版年：April, 2014
• 年：2014
• 卷：35
• 期：4
• 页码：899-905
• 全文大小：469 K

文摘

In cerebral amyloid angiopathy patients, microbleeds often cluster, mostly occipital, and are associated with apolipoprotein E (APOE) genotype. Microbleeds also frequently occur in the asymptomatic, general population. In this population, we investigated spatial distribution of microbleeds and whether this is influenced by APOE genotype. In 292 persons with microbleeds, we labeled microbleeds on baseline and follow-up magnetic resonance images. We calculated distance between incident and prevalent microbleeds within and between persons and performed lobar segmentation on the magnetic resonance images. Subsequently, we investigated proximity and lobar distribution in strata of APOE genotype. Microbleeds occurred closer within persons than between persons (鈭?2.2 mm, 95% confidence interval, 鈭?4.6 to聽鈭?9.9; p < 0.001). Microbleeds within APOE 蔚2 and 蔚4 carriers occurred closer than those in persons with 蔚3蔚3 genotype (鈭?1.9 mm, 95% confidence interval,聽鈭?4.4 to 0.6; p聽= 0.06). Persons with 蔚2 and 蔚4 alleles had a larger proportion of microbleeds in the occipital lobe than persons with 蔚3蔚3 genotype. Similar to cerebral amyloid angiopathy patients, microbleeds in the general population cluster and the distribution is affected by APOE genotype.