Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway

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• 作者：Madoka Chinen ; Elissa P. Lei ; ^{leielissa@niddk.nih.gov}
• 关键词：Argonaute ; RNAi ; Protein stability ; Ubiquitin ; Proteasome
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：12 February 2017
• 年：2017
• 卷：483
• 期：3
• 页码：951-957
• 全文大小：1451 K
• 卷排序：483

文摘

Mutation of the PIWI domain in Drosophila Argonaute2 (AGO2) causes protein instability. Ubiquitin proteasome components co-purify with AGO2. The turnover of AGO2 is regulated by the ubiquitin proteasome pathway.