GSTM1 and GSTP1, but not GSTT1 genetic polymorphisms are associated with chronic myeloid leukemia risk and treatment response
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- 作者：Natalia Weicha ; Cristian Ferria ; Beatriz Moiraghib ; Raquel Bengió ; c ; Isabel Giered ; Carolina Pavlovskyd ; Irene B. Larripaa ; 1 ; Ariela F. Fundiaa ; 1 ; affundia@hematologia.anm.edu.ar" class="auth_mail" title="E-mail the corresponding author ; arielafundia@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glutathione-S-transferases ; Genetic polymorphisms ; Chronic myeloid leukemia risk ; Treatment outcome
- 刊名：Cancer Epidemiology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：16-21
- 全文大小：609 K
文摘
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GSTM1, GSTT1 and GSTP1 were studied in chronic myeloid leukemia patients and controls to assess their role on disease risk and treatment response.
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A trend toward significance was found for GSTP1 for a recessive model suggesting a potential association with the CML risk in Argentinean patients.
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Patients carrying combined GSTM1-null/GSTP1-GG or GSTT1-null/GSTP1-GG genotypes were associated with CML susceptibility.
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Patients with GSTM1 gene as well GSTP1-GG genotype were associated to treatment failure
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This study highlights the identification of GST markers associated to CML susceptibility and treatment response.