In silico study on the effects of matrix structure in controlled drug release

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• 作者：Rafael Villalobos ; Salom&#xf3 ; n Cordero ; Ana Maria Vidales and Armando Domí ; nguez
• 关键词：Drug release ; Dual site– ; bond model ; Inert matrix ; Monte Carlo simulation ; Weibull equation
• 刊名：Physica A
• 出版年：2006
• 出版时间：15 July 2006
• 年：2006
• 卷：367
• 期：Complete
• 页码：305-318
• 全文大小：320 K

文摘

Purpose: To study the effects of drug concentration and spatial distribution of the medicament, in porous solid dosage forms, on the kinetics and total yield of drug release.

Methods: Cubic networks are used as models of drug release systems. They were constructed by means of the dual site–bond model framework, which allows a substrate to have adequate geometrical and topological distribution of its pore elements. Drug particles can move inside the networks by following a random walk model with excluded volume interactions between the particles. The drug release time evolution for different drug concentration and different initial drug spatial distribution has been monitored.

Results: The numerical results show that in all the studied cases, drug release presents an anomalous behavior, and the consequences of the matrix structural properties, i.e., drug spatial distribution and drug concentration, on the drug release profile have been quantified.

Conclusions: The Weibull function provides a simple connection between the model parameters and the microstructure of the drug release device. A critical modeling of drug release from matrix-type delivery systems is important in order to understand the transport mechanisms that are implicated, and to predict the effect of the device design parameters on the release rate.