β-arrestin is critical for early shear stress-induced Akt/eNOS activation in human vascular endothelial cells

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• 作者：Ana Paula Carneiro¹ ; Miriam Helena Fonseca-Alaniz¹ ; Luí ; s Alberto Oliveira Dallan ; Ayumi Aurea Miyakawa ; Jose Eduardo Krieger ; ^{krieger@incor.usp.br}
• 关键词：β-arrestin ; Mechanotransduction ; Shear stress ; Nitric oxide ; Endothelial cells
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：75-81
• 全文大小：1185 K
• 卷排序：483

文摘

β-arrestins is a key integrator on laminar SS-induced NO generation. β-arrestins and caveolin-1 are part of the cellular mechanotransduction machinery. β-arrestins and Akt/eNOS downstream signaling are required for early SS-induced NO production.