Effects of phosphate binders on the gastrointestinal absorption of arsenate and of an SGLT2 inhibitor drug on the urinary excretion of arsenite in mice

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• 作者：Mikló ; s Poó ; r^a ; ^b ; Balá ; zs Né ; meti^a ; ^b ; Zoltá ; n Gregus^b ; ^{zoltan.gregus@aok.pte.hu}
• 关键词：Arsenic ; Aluminium hydroxide ; Lanthanum carbonate ; Sevelamer ; Dapagliflozin ; SGLT2
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：179-187
• 全文大小：1844 K
• 卷排序：49

文摘

Phosphate binders bind and precipitate arsenate in vitro (La3+ > Al3+ > sevelamer). Orally dosed La3+ or Al3+ compounds decrease absorption of arsenate gavaged to mice. Dapagliflozin causes glycosuria but does not increase the urinary excretion of arsenite. Na+-dependent glucose transporter-2 plays no role in renal reabsorption of arsenite.