Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38
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- 作者：A. Rosal-Velaa ; 1 ; A. Barrosob ; 1 ; E. Gimé ; nezb ; S. Garcí ; a-Rodrí ; gueza ; V. Longobardoc ; J. Postigod ; M. Iglesiasd ; A. Larioc ; J. Merinod ; R. Merinoe ; M. Zubiaura ; V. Sanz-Nebotb ; J. Sanchoa ; granada@ipb.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：CIA ; collagen-type-II-induced arthritis ; WT ; wild-type ; CFA ; complete Freund's adjuvant ; IFA ; incomplete Freund's adjuvant ; RA ; rheumatoid arthritis
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：134
- 期：Complete
- 页码：127-137
- 全文大小：1129 K
文摘
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23 different spleen protein species were able to discriminate between WT and CD38-KO mice upon Collagen-II immunization.
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Among them, multiple serotransferrin (Tf) species, and a number of citrullinated protein species were identified.
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μLC-TOF-MS revealed differences in the serum Tf glycosylation pattern between CD38-KO and WT mice with arthritis.
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Data on Tf spots separated by 2-DE (i.e.: protein species) indicated differences in glycosylation related with their NeuGc content.