Isolation and structural characterization of novel photolytic degradation impurities of Deflazacort using Q-TOF, 2D-NMR and FTIR

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• 作者：Ch Krishnam Raju ; Avadhesh Kumar Pandey ; Kaushik Ghosh ; Arunima Pola ; Sanath Kumar Goud ; ^skg@usp.org ; Mrunal A. Jaywant ; Sameer G. Navalgund ; Koduru V. Surendranath
• 关键词：Deflazacort ; UV degradation ; Q-TOF ; NMR ; FTIR ; Novel impurities
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：133
• 期：Complete
• 页码：82-89
• 全文大小：1250 K
• 卷排序：133

文摘

Forced degradation of Deflazacort in ultra-violet (light) condition. Isolation and characterization of 2 novel degradation products. Structural elucidation using MS-qTOF, 1D/2D NMR, IR.