CH Arylation using acyl thiourea ligands: Applications in the synthesis of 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

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• 作者：Aamer Saeed ; ^{asaeed@qau.edu.pk" class="auth_mail" title="E-mail the corresponding author} ; ^{aamersaeed@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Pervaiz Ali Channar ; Qasir Iqbal ; Jamaluddin Mahar
• 关键词：[1 ; 2 ; 4]Triazolo[3 ; 4-b] [1 ; 3 ; 4]thiadiazoles ; Acyl thiourea ; CH arylative coupling ; N ; N-Dimethylacetamide
• 刊名：Chinese Chemical Letters
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：27
• 期：1
• 页码：37-40
• 全文大小：472 K

文摘

Synthesis of a series of new 3,6-diaryl-[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazoles (5a–o) was achieved by phophine free, Cbond" data-inlimg="/entities/sbnd" src="/sd/grey_pxl.gif" class="glyphImg imgLazyJSB">H arylative cross-coupling of 6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (4a–o) with suitably substituted iodoanilines using 1-(2-naphthoyl)-3-(4-bromophenyl)thiourea as a ligand. The requisite triazolothiadiazoles (4a–o) were obtained by the condensation of 4-amino-1,2,4-triazole-3-thiol (3) with suitably substituted aromatic acids in the presence of phosphoryl chloride.