刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1271-1277
全文大小:1181 K
卷排序:482
文摘
ΔN-ASPP2 is a N-terminal truncated ASPP2 isoform. ΔN-ASPP2 antagonizes p53 transactivation and p53 promoter occupancy after cellular stress. ΔN-ASPP2 promotes cell proliferation and suppresses cytotoxic damage-induced growth inhibition and apoptosis. ΔN-ASPP2 is overexpressed in human breast tumors compared to adjacent normal breast tissue.