Safety and Efficacy of Granulocyte Colony-Stimulating Factor Monotherapy for Peripheral Blood Stem Cell Collection in POEMS Syndrome

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• 作者：Tomoya Muto¹ ; Chikako Ohwada¹ ; ^{chikako_ohwada@faculty.chiba-u.jp} ; Koji Takaishi¹ ; Yusuke Isshiki¹ ; Yuhei Nagao¹ ; Nagisa Hasegawa¹ ; Chika Kawajiri-Manako¹ ; Emi Togasaki¹ ; Ryoh Shimizu¹ ; Shokichi Tsukamoto¹ ; Shio Sakai¹ ; ² ; Yusuke Takeda¹ ; Naoya Mimura¹ ; ² ; Masahiro Takeuchi¹ ; Emiko Sakaida¹ ; Sonoko Misawa³ ; Naomi Shimizu⁴ ; Tohru Iseki¹ ; ² ; Satoshi Kuwabara³ ; Chiaki Nakaseko¹
• 关键词：POEMS syndrome ; Stem cell mobilization ; Granulocyte colony&ndash ; stimulating factor ; Stem cell transplantation
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：2
• 页码：361-363
• 全文大小：108 K
• 卷排序：23

文摘

The safety and efficacy of peripheral blood stem cell collecting procedures in POEMS syndrome were investigated The proportions of good mobilizers were comparable between cyclophosphamide plus granulocyte colony–stimulating factor or granulocyte colony–stimulating factor alone mobilization Mobilization-related complications were significantly higher in the cyclophosphamide plus granulocyte colony–stimulating factor  group Patients in granulocyte colony–stimulating factor alone group achieved a significant decrease in the serum vascular endothelial growth factor levels by induction therapy before peripheral blood stem cell collection Appropriate induction therapy followed by granulocyte colony–stimulating factor monotherapy is an optimal strategy for peripheral blood stem cell collection in POEMS syndrome