Functional characterization and inhibition of the type II DNA topoisomerase coded by African swine fever virus
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- 作者：Joã ; o Coelho ; jnscoelho@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Fernando Ferreira ; Carlos Martins ; Alexandre Leitã ; o ; alexandre@fmv.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：African swine fever virus ; ASFV ; P1192R ; DNA Topoisomerases ; Type II ; Topoisomerase II inhibitors ; Amsacrine ; Doxorubicin ; Ciprofloxacin
- 刊名：Virology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：493
- 期：Complete
- 页码：209-216
- 全文大小：1090 K
文摘
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ASFV pP1192R is active under conditions similar for other type II topoisomerases.
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pP1192R catenates, decatenates and relaxes DNA, but does not supercoil relaxed DNA.
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pP1192R׳s activity is processive.
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Activity of pP1192R is inhibited by common topoisomerase II poisons and inhibitors.
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Doxorubicin, coumermycin A1 and m-AMSA had the highest effect on pP1192R activity.