Asiaticoside attenuates memory impairment induced by transient cerebral ischemia-reperfusion in mice through anti-inflammatory mechanism
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- 作者：She Chena ; Zhu-Jun Yina ; Chen Jiangb ; Zhan-Qiang Maa ; Qiang Fua ; fuqiang@cpu.edu.cn" class="auth_mail ; Rong Quc ; qur2004@yahoo.com.cn" class="auth_mail ; Shi-Ping Maa ; spma@cpu.edu.cn" class="auth_mail
- 关键词：Asiaticoside ; Cerebral ischemia ; Reperfusion ; Memory impairment ; Inflammation
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：July 2014
- 年：2014
- 卷：122
- 期：Complete
- 页码：7-15
- 全文大小：1120 K
文摘
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AS attenuates memory impairment induced by transient cerebral ischemia–reperfusion.
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AS exhibits anti-inflammation activity in cerebral ischemia–reperfusion in mice.
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The effects of AS may be related to anti-inflammation and inhibition of microglia.
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AS may play its anti-inflammation activity via suppression of p38 MAPK pathway.
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AS may be a candidate therapy for ischemic brain injury.