Effects of a supplement combining Pycnogenol^® and l-arginine aspartate on lower urinary dysfunction compared with saw palmetto extract

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• 作者：Hiroshi Yagi ; ^{hyagi@dokkyomed.ac.jp} ; Ryo Sato ^{ryo-sato@dokkyomed.ac.jp} ; Kojiro Nishio ^{kou240@gmail.com} ; Gaku Arai ^{g-arai@dokkyomed.ac.jp} ; Shigehiro Soh ^{ssong@dokkyomed.ac.jp} ; Hiroshi Okada ^{hirooka@dokkyomed.ac.jp}
• 关键词：Lower urinary tract symptoms ; Sexual dysfunction ; Pycnogenol® ; Saw palmetto ; Oxidative stress
• 刊名：Journal of Traditional and Complementary Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：7
• 期：1
• 页码：117-120
• 全文大小：165 K
• 卷排序：7

文摘

Lower urinary tract symptoms (LUTS) and sexual dysfunction (SDys) are common problems that affect quality of life (QOL) in elderly men. In addition to prescribed drugs, many over-the-counter medications including supplements are used to treat QOL diseases. Phosphodiesterase inhibitors are reported to be effective for both LUTS and SDys by increasing nitric oxide levels. French maritime pine bark extract Pycnogenol®, which is a potent nitric oxide donor, is reported to be effective for SDys. However, no reports have been published on whether it ameliorates LUTS.DesignOpen-labeled, randomized study. The effects of two supplements, Nokogiriyashi EX® containing 160 mg saw palmetto (SP) extract per tablet and Edicare® containing 10 mg of Pycnogenol®, 115 mg of l-arginine and 92 mg of aspartate (PAA) per tablet on International Prostate Symptom Score (IPSS), IPSS–QOL, Overactive Bladder Symptom Score (OABSS), International Index of Erectile Function 5 (IIEF5), Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), urinary 8-OHdG and uroflowmetry (UFM) of total 40 men with LUTS and SDys were examined.Results19 subjects were instructed to take two tablets of SP, on the other 20 were on four tablets of PAA for 16 weeks. IPSS and IPSS–QOL showed statistically significant improvements in both groups. OABSS and IIEF5 were significantly improved in the PAA group. Conversely, ICIQ-SF, 8-OHdG and UFM did not change in either group.ConclusionsPAA might be an effective therapeutic alternative for elderly patients with LUTS and SDys.