Mitochondria as Molecular Platforms Integrating Multiple Innate Immune Signalings

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• 作者：Marie Monlun¹ ; ² ; Caroline Hyernard¹ ; ² ; Patrick Blanco¹ ; ² ; ³ ; Lydia Lartigue⁴ ; Benjamin Faustin¹ ; ² ; ^{bfaustin@cirid.org} ; ^{benfaustin@gmail.com}
• 关键词：DC ; dendritic cell ; PRR ; pattern recognition receptor ; PAMP ; pathogen-associated molecular pattern ; DAMP ; danger-associated molecular pattern ; MAPK ; mitogen-activated protein kinase ; IFN ; interferon ; TLR ; Toll-like receptor ; NLR ; nucleotide-oligomerization domain-like receptor ; RIG-I ; retinoic acid-inducible gene-I ; RLR ; RIG-I-like receptor ; OXPHOS ; oxidative phosphorylation ; MAVS ; mitochondrial antiviral signaling ; OMM ; outer mitochondrial membrane ; mtROS ; mitochondrial reactive oxygen species
• 刊名：Journal of Molecular Biology
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：429
• 期：1
• 页码：1-13
• 全文大小：716 K
• 卷排序：429

文摘

Mitochondria are «bacteria within» that are crucially involved in multiple host innate immune responses to infection (bacteria and viruses) and sterile cell stress. Mitochondrial function seems to control innate immunity at various stages as diverse as the transcriptional regulation of inflammatory cytokines and chemokines and their maturation by inflammasomes. Mitochondria orchestrate innate immune responses at different levels by promoting a cellular metabolic reprogramming and the cytosolic immune signaling cascades. Mitochondria host a myriad of molecular components involved in innate immune machineries. Mitochondria integrate innate immune sensing of pathogens and cell stress and propagate signals through the release of its components to alert cytosolic sentinels.