Asthma and rhinitis have different genetic profiles for IL13, IL17A and GSTP1 polymorphisms

详细信息    查看全文

• 作者：E.P. Resende^a ; ^{eresende@fmed.uc.pt} ; A. Todo-Bom^b ; ^d ; C. Loureiro^b ; A. Mota Pinto^c ; ^d ; B. Oliveiros^e ; L. Mesquita^a ; H.C. Silva^a ; ^d
• 关键词：Asthma ; Rhinitis ; Allergy ; IL4R ; IL13 ; IL17A ; GSTP1 ; Genetic polymorphism ; Genetic profile
• 刊名：Revista Portuguesa de Pneumologia (English Edition)
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：23
• 期：1
• 页码：10-16
• 全文大小：435 K
• 卷排序：23

文摘

Asthma and rhinitis have a complex etiology, depending on multiple genetic and environmental risk factors. An increasing number of susceptibility genes are currently being identified, but the majority of reported associations have not been consistently replicated across populations of different genetic backgrounds.PurposeTo evaluate whether polymorphisms of IL4R (rs1805015), IL13 (rs20541), IL17A (rs2275913) and GSTP1 (rs1695) genes are associated with rhinitis and/or asthma in adults of Portuguese ancestry.Methods192 unrelated healthy individuals and 232 patients, 83 with rhinitis and 149 with asthma, were studied. All polymorphisms were detected by real time polymerase chain reaction (PCR) using TaqMan assays.ResultsComparing to controls, significant association with asthma was observed for GSTP1 rs1695 AA genotype (odds ratio (OR) – 1.96; 95% CI – 1.18 to 3.25; p = 0.010). The association sustains for allergic asthma (OR – 2.17; 95% CI – 1.23 to 3.80; p = 0.007). IL13 rs20541 GG genotype was associated with less susceptibility to asthma (OR – 0.55, 95% CI – 0.33 to 0.94, p = 0.028). Among patients, IL17A rs2275913 AA genotype was less associated with asthma than with rhinitis (OR – 0.20; 95% CI of 0.07 to 0.56; p = 0.002). A similar association was found for IL13 rs20541 GG genotype (OR – 0.48; 95% CI of 0.25 to 0.93; p = 0.031). There were no significant differences in the distribution of allelic and genotypic frequencies between patients and controls for the IL4R polymorphism’ analyzed.ConclusionThese results support the existence of a significant association between GSTP1 rs1695 and IL13 rs20541 SNPs, with susceptibility to asthma, in the population studied. Different genotype profiles of IL17A and IL13 genes seem to influence the clinical pattern of disease expression mainly confined to the upper airways, as rhinitis, or including the lower airways, as asthma.