The role of spinal interleukin-1β and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model
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- 作者：Hoon-Seong Choia ; Dae-Hyun Rohb ; Seo-Yeon Yoonc ; Soon-Gu Kwonb ; Sheu-Ran Choia ; Suk-Yun Kangd ; Ji-Young Moond ; Ho-Jae Hana ; Hyun-Woo Kime ; Alvin J. Beitzf ; Jang-Hern Leea ; jhl1101@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mirror-image pain ; Interleukin-1ß ; Astrocyte ; Connexin 43
- 刊名：Experimental Neurology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：287
- 期：part_P1
- 页码：1-13
- 全文大小：1275 K
文摘
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CA rats showed a delayed increase of contralateral MA and spinal Cx43 expression.
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Blocking of spinal IL-1β advanced the development of contralateral MA.
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Blocking of spinal IL-1β upregulated the spinal Cx43 expression.
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Inhibition of astrocyte GJ restored the IL-1ra-evoked early contralateral MA and spinal Cx43 expression.
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