Highly enantioselective Michael addition of malononitrile to α,β-unsaturated pyrazolamides catalyzed by a bifunctional thiourea

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• 作者：Yuanqin Zheng^a ; Yongqi Yao^a ; Ling Ye^b ; Zhichuan Shi^a ; Xuefeng Li^a ; ^{lixuefeng@swun.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhigang Zhao^a ; ^{zzg63129@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xinying Li^a
• 关键词：Enantioselective ; Michael addition ; Malononitrile ; α ; β-Unsaturated pyrazolamide ; Bifunctional thiourea
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：18 February 2016
• 年：2016
• 卷：72
• 期：7
• 页码：973-978
• 全文大小：510 K

文摘

A new protocol for the organocatalytic asymmetric Michael addition of malononitrile to α,β-unsaturated pyrazolamides is reported. The Michael reaction proceeded smoothly in the presence of a bifunctional thiourea and provided the desired adducts in moderate to excellent yields (27–99%) and good to excellent enantioselectivities (80–95% ee).