Synthetic study of biphenylquinolizidine alkaloids I. Asymmetric total synthesis of lasubine I featuring organocatalyzed asymmetric intramolecular aza-Michael addition

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• 作者：Taku Hirama ; Takayuki Umemura ; Noriyuki Kogure ; Mariko Kitajima ; Hiromitsu Takayama ; ^{takayamah@faculty.chiba-u.jp}
• 关键词：Quinolizidine alkaloid ; Lasubine I ; Organocatalyst ; aza-Michael addition ; Asymmetric synthesis
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：58
• 期：3
• 页码：223-226
• 全文大小：652 K
• 卷排序：58

文摘

An organocatalyzed asymmetric intramolecular aza-Michael addition of linear dienone was developed. A new synthetic method of chiral 4-arylquinolizidinone was developed. A novel and efficient total synthesis of lythraceous alkaloid, lasubine I, was accomplished.