ATF3 modulates calcium signaling in osteoclast differentiation and activity by associating with c-Fos and NFATc1 proteins

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• 作者：Byung-Chul Jeong^a ; ^b ; ^c ; ¹ ; Jung Ha Kim^a ; ¹ ; Kabsun Kim^a ; Inyoung Kim^a ; Semun Seong^a ; ^b ; Nacksung Kim^a ; ^b ; ^{nacksung@jnu.ac.kr}
• 关键词：ATF3 ; activating transcription factor ; BMM ; bone marrow-derived monocyte/macrophage lineage cell ; NFATc1 ; nuclear factor of activated T-cells c1 ; TRAP ; tartrate-resistant acid phosphatase ; RANKL ; receptor activator of nuclear factor-κB ligand
• 刊名：Bone
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：33-40
• 全文大小：1412 K
• 卷排序：95

文摘

ATF3 expression was regulated during osteoclast differentiation. Overexpression of ATF3 enhanced osteoclast differentiation and activity. Inhibition of ATF3 resulted in reduced osteoclastogenesis. ATF3 synergistically enhanced promoter activity of TRAP and NFATc1 by associating with NFAT and c-Fos. ATF3 modulated calcium-signaling cascade during osteoclastogenesis.