Can we predict new AF occurrence in single-chamber ICD patients? Insights from an observational investigation

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• 作者：Mauro Biffi^a ; ¹ ; ² ; Matteo Ziacchi^a ; ¹ ; Renato Pietro Ricci^b ; ¹ ; Domenico Facchin^c ; ¹ ; Giovanni Morani^d ; ¹ ; Maurizio Landolina^e ; ¹ ; Maurizio Lunati^f ; ¹ ; Saverio Iacopino^g ; ¹ ; Alessandro Capucci^h ; ¹ ; Stefano Bianchiⁱ ; ¹ ; Tommaso Infusino^j ; ¹ ; Giovanni Luca Botto^k ; ¹ ; Luigi Padeletti^l ; ^m ; ³ ; Giuseppe Borianiⁿ ; ³
• 关键词：Atrial fibrillation ; CHADS2 score ; Atrial fibrillation diagnosis ; single chamber defibrillator
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：230
• 期：Complete
• 页码：275-280
• 全文大小：432 K
• 卷排序：230

文摘

Atrial tachyarrhythmias (AT/AF) have been associated with an increased risk of mortality, morbidity and ischemic stroke. Up to now, single chamber ICD diagnostics was not able to detect AT/AF, therefore the incidence of new onset AT/AF in patients with single chamber ICD is not known.ObjectiveTo evaluate incidence and predictors of AT/AF occurrence in patients with dual-chamber ICD with no pacing indications and no history of AT/AF that strictly mimic single chamber ICD recipient.Methods & resultsConsecutive dual-chamber ICD patients were prospectively followed by 47 Italian cardiologic centers in an observational research. Clinical and device data were reviewed by expert cardiologists to assess AT/AF occurrence. Multivariate regression analysis evaluated the risk of new-onset AT/AF and its association with patients' baseline characteristics and with CHADS2 score.428 (13.4% female, 64 years old) patients were followed for a median observation period of 31 months. AT/AF episodes occurred in 160 (37.4%) patients when considering at least 5 min duration, in 95 (22.2%) for AT/AF ≥ 6 h, in 47 (11.0%) for AT/AF ≥ 1 day, in 29 (6.8%) for AT/AF ≥ 7 days. Patients with CHADS2 ≥ 2, who comprised 36% of the whole population, showed higher incidence of AT/AF ≥ 6 h compared with patients with CHADS2 < 2 (Hazard Ratio = 1.69, 95% Confidence Interval = 1.13–2.53, p = 0.011).ConclusionsOur observations in a population of dual-chamber ICD patients with no pacing indications and no history of AT/AF, who strictly mimic single–chamber ICD recipients, highlight that AT/AF episodes occurred in the 37.5% of the population and CHADS2 score is predictive of new-onset AT/AF.