ChAT-positive neurons participate in subventricular zone neurogenesis after middle cerebral artery occlusion in mice
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- 作者：Jianping Wang ; MD ; PhDa ; 1 ; wjpwfy666@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiaojie Fua ; 1 ; Di Zhanga ; Lie Yua ; Nan Lia ; Zhengfang Lua ; Yufeng Gaoa ; Menghan Wanga ; Xi Liua ; Chenguang Zhoua ; Wei Hana ; Bo Yanb ; Jian Wang ; MD ; PhDa ; c ; jwang79@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ChAT+ neurons ; Stroke ; Neurogenesis ; Subventricular zone
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：145-151
- 全文大小：2199 K
文摘
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SVZ choline acetyltransferase (ChAT)+ neurons promote neurogenesis in adult mice.
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SVZ neurogenesis was elevated after middle cerebral artery occlusion (MCAO) in mice.
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The cholinergic system in the SVZ was activated after MACO.
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Post-stroke neurogenesis was enhanced by donepezil and abolished by atropine.
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SVZ ChAT+ neurons may promote neurogenesis via the FGFR signaling pathway.
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