Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype
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- 作者：Shingo Sato1 ; 2 ; 3 ; Yuning J. Tang1 ; 4 ; Qingxia Wei1 ; Makoto Hirata1 ; Angela Weng1 ; Ilkyu Han5 ; Atsushi Okawa2 ; Shu Takeda3 ; Heather Whetstone1 ; Puvindran Nadesan4 ; David G. Kirsch6 ; 7 ; Jay S. Wunder8 ; Benjamin A. Alman1 ; 4 ; ben.alman@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 July 2016
- 年：2016
- 卷：16
- 期：4
- 页码：917-927
- 全文大小：3421 K
文摘
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Pericytes can be a cell of origin for benign and malignant mesenchymal neoplasms
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Malignant sarcomas show a decrease in β-catenin signaling compared to pericytes
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Benign desmoids show an increase in β-catenin signaling compared to pericytes