The role of peroxiredoxin 4 in inflammatory response and aging
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- 作者：Vladimir I. Klichko ; William C. Orr ; Svetlana N. Radyuk ; snradyuk@smu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER ; endoplasmic reticulum ; Prx ; peroxiredoxin ; AMP ; antimicrobial peptide ; UPR ; unfolded protein response ; Act ; actin ; Da ; daughterless ; AttD ; attacin D ; Dipt ; diptericin ; Drs ; drosomycin ; TotA ; Turandot A ; ROS ; reactive oxygen species
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1862
- 期：2
- 页码：265-273
- 全文大小：1218 K
文摘
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Peroxiredoxin 4 controls the immune and cell death responses via NF-κB analog Relish.
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The immune responses to abiotic stimuli require Peroxiredoxin 4 activity in the ER.
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Overactivation of the immune/inflammatory responses is lessened by JAK/STAT signaling.
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Neuronal overexpression of Peroxiredoxin 4 confers beneficial effects on longevity.