3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression
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- 作者：Pietro Rizzaa ; 1 ; Michele Pellegrinoa ; 1 ; Anna Carusoa ; 1 ; Domenico Iacopettaa ; 1 ; Maria Stefania Sinicropia ; s.sinicropi@unical.it" class="auth_mail" title="E-mail the corresponding author ; Sylvain Raultb ; sylvain.rault@unicaen.fr" class="auth_mail" title="E-mail the corresponding author ; Jean Charles Lancelotb ; Hussein El-Kashefc ; Aurelien Lesnardb ; Christophe Rochaisb ; Patrick Dallemagneb ; Carmela Saturninod ; Francesca Giordanoa ; Stefania Catalanoa ; Sebastiano Andò ; a ; sebastiano.ando@unical.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-(Alkyl(dialkyl)amino)-benzofuro[2 ; 3-f]quinazolin-1(2H)-one analogs ; 3-(dipropylamino)-5-hydroxybenzofuro[2 ; 3-f]quinazolin-1(2H)-one ; Dibenzofuran derivatives ; One-pot reaction ; Apoptosis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：275-287
- 全文大小：1454 K
文摘
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A series of 3-(alkyl(dialkyl)amino)benzofuro[2,3-f]quinazolin-1(2H)-ones was reported.
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The synthesis of these benzofuroquinazolinones was performed in a one-pot reaction.
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class="boldFont">DPA-HBFQ-1 inhibits ERα+, ERα− and tamoxifen-resistant breast cancer cells growth.