Management of rheumatic and autoimmune blistering disease in pregnancy and postpartum

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• 作者：Joy Wan ; MD^a ; ¹ ; Sotonye Imadojemu ; MD ; MBE^b ; ¹ ; Victoria P. Werth ; MD^a ; ^c ; ^{Werth@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Clinics in Dermatology
• 出版年：2016
• 出版时间：May-June 2016
• 年：2016
• 卷：34
• 期：3
• 页码：344-352
• 全文大小：426 K

文摘

The treatment of rheumatic and autoimmune skin disease in women who are pregnant or of childbearing potential can present challenges to the dermatologist. We discuss the current approaches to treating lupus erythematosus, antiphospholipid antibody syndrome, dermatomyositis, morphea and systemic sclerosis, mixed connective tissue disease, rheumatoid arthritis, and autoimmune blistering disease in such patients. In the appropriate setting, topical and systemic corticosteroids, hydroxychloroquine, dapsone, azathioprine, and ultraviolet B phototherapy may be safely and cautiously used during pregnancy. Considerations about contraception, planned conception, therapeutic options, and disease control are paramount in optimizing pregnancy outcomes and minimizing risks to both mother and fetus.