PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

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• 作者：Florian Wiede ; Faruk Sacirbegovic ; Yew Ann Leong ; Di Yu ; Tony Tiganis ; ^{Tony.Tiganis@monash.edu}
• 关键词：PTPN2 ; Inflammation ; Autoimmunity ; Tfh cell ; B cell ; Hematopoiesis
• 刊名：Journal of Autoimmunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：85-100
• 全文大小：4787 K
• 卷排序：76

文摘

Hematopoietic PTPN2-deficiency promotes systemic inflammation and autoimmunity. PTPN2-deficiency enhances T cell and B cell responses. PTPN2 deficiency increases Tfh cell generation. PTPN2 deficiency promotes IL-21-induced STAT3 signalling in B cells and Tfh cells.