Serum cross-reaction among virulence-associated trimeric autotransporters (VtaA) of Haemophilus parasuis

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• 作者：Alex Olvera^a ; ^b ; ² ; Veró ; nica Martí ; nez-Moliner^b ; Sonia Pina-Pedrero^b ; ^c ; Marta Pé ; rez-Simó ; ^b ; Nuria Galofré ; -Milà ; ^b ; Mar Costa-Hurtado^b ; Virginia Aragon^b ; ^c ; ¹ ; Albert Bensaid^b ; ¹ ; ^{Albert.Bensaid@cresa.uab.cat}
• 关键词：VtaA ; Cross-reaction ; Trimeric autotransporters ; Haemophilus parasuis
• 刊名：Veterinary Microbiology
• 出版年：2013
• 出版时间：28 June, 2013
• 年：2013
• 卷：164
• 期：3-4
• 页码：387-391
• 全文大小：546 K

文摘

Gl?sser's disease is a fibrinous polyserositis and polyarthritis of swine caused by the bacterium Haemophilus parasuis. Control by vaccination has been limited for years due to lack of cross-protection among strains. However, 6 trimeric autotransporters (VtaA) of the Nagasaki strain were shown to be antigenic and gave partial protection to a lethal challenge. The antigenic relationship among the VtaAs was examined by immunizing mice with individual VtaA showing that they cross-reacted by ELISA mainly with VtaA from the same group. When sera from protected and non-protected vaccinated piglets were examined no differences in VtaA cross-reactivity profiles were found. In addition, sera from commercial pigs immunized with a single VtaA (VtaA9) showed a wider range of VtaA cross-reaction, probably due to the previous colonization by H. parasuis. These results can help the development of new vaccine formulations against H. parasuis by allowing a rational VtaA selection.