Acute and subchronic toxicological evaluation of Mequindox in Wistar rats

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• 作者：Awais Ihsan ; Xu Wang ; Xian-ju Huang ; Yu Liu ; Qin Liu ; Wen Zhou ; Zong-hui Yuan
• 关键词：Acute ; Mequindox ; Quinoxalines ; Subchronic ; Toxicity ; Wistar rats
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2010
• 出版时间：July-August 2010
• 年：2010
• 卷：57
• 期：2-3
• 页码：307-314
• 全文大小：493 K

文摘

We studied an acute and subchronic oral toxicity of Mequindox (MEQ), a quinoxaline 1,4-dioxide antimicrobial promoter, in Wistar rats according to OECD guidelines. For acute toxicity study, single doses of MEQ at 175, 550 and 2000 mg/kg b.w. were administered to rats by oral gavage. The calculated LD₅₀ was 550 mg/kg b.w. In subchronic study, rats were fed diets containing 0, 55, 110 or 275 mg MEQ/kg. There was a reduction in body weight of rats fed 275 mg MEQ/kg diet. At 90 days autopsy, a significant decrease in the kidney weight was observed in males while an increase in relative liver and adrenal weights were observed in females fed 275 mg MEQ/kg diet. There was a significant increased in alanineaminotransferase (ALT) and malondialdehyde (MDA) concentrations in males, superoxide dismutase (SOD) activities in females, and aspartateaminotransferase (AST) levels in serum of both genders fed 275 mg MEQ/kg diet. Other toxic effects of 275 mg MEQ/kg diet included significant decrease in sodium and significant increase in potassium concentrations in serum in both genders. We may conclude that MEQ can induce hepatic and adrenal histological changes as well as leaking of different serum constituents in Wistar rats.